Biomedical Supplements

Biomedical Supplements

Purpose of Biomedical Supplements

Achieving Wellness: Acute episodes of any severe Psychiatric Disorder including severe Depression, Bipolar Disorders and Schizophrenia are serious medical conditions that affect mental, physical and personal wellness. They may require combinations of short-term psychiatric inpatient hospitalization, medications, counseling and life style changes to stabilize symptoms and achieve stabilization. Additional psychiatric outpatient and various adjunct treatment modalities are helpful for optimum functional recovery. Recovery of normal function is related to inflammatory processes that need to be reversed – see the page on Neuro-inflammation on this website.

This page provides information on Biomedical Supplements. While there are many supplements this page is focused on a few supplements with the best research evidence and efficacy in Mental Health conditions.

 

Omega-3 Fatty Acids:

Omega-3 fatty acids are a type of polyunsaturated fatty acid that are essential for human health but cannot be produced by the body and must be obtained from dietary sources. They play crucial roles in various physiological processes and have been linked to numerous health benefits. There are three main types of omega-3 fatty acids:

  1. Alpha-Linolenic Acid (ALA): ALA is found primarily in plant sources such as flaxseeds, chia seeds, hemp seeds, walnuts, and certain vegetable oils (e.g., flaxseed oil, canola oil, soybean oil). It is considered an essential fatty acid because the body can convert it into the other two types of omega-3 fatty acids, EPA and DHA, although this conversion is relatively inefficient.
  2. Eicosapentaenoic Acid (EPA): EPA is found primarily in fatty fish such as salmon, mackerel, sardines, and trout, as well as in fish oil supplements. EPA is known for its anti-inflammatory properties and has been studied for its potential benefits for cardiovascular health, mood disorders, and inflammatory conditions such as rheumatoid arthritis.
  3. Docosahexaenoic Acid (DHA): DHA is also found primarily in fatty fish and fish oil supplements. It is particularly important for brain health and development, as well as for the health of the eyes and nervous system. DHA is a major component of cell membranes in the brain and retina.

Health Benefits of Omega-3 Fatty Acids:

  1. Heart Health: Omega-3 fatty acids have been shown to reduce the risk of heart disease by lowering triglyceride levels, reducing blood pressure, improving endothelial function, and reducing inflammation. They may also help prevent the formation of blood clots and plaque buildup in the arteries.
  2. Brain Health: DHA, in particular, is essential for brain development and function throughout all stages of life. Omega-3 fatty acids may help improve cognitive function, memory, and mood and may reduce the risk of age-related cognitive decline and neurodegenerative diseases such as Alzheimer’s disease.
  3. Eye Health: DHA is a major component of the retina, and omega-3 fatty acids may help protect against age-related macular degeneration (AMD) and dry eye syndrome. Adequate intake of omega-3 fatty acids during pregnancy and infancy is also important for the development of vision.
  4. Inflammatory Conditions: Omega-3 fatty acids have anti-inflammatory properties and may help reduce symptoms of inflammatory conditions such as rheumatoid arthritis, inflammatory bowel disease (IBD), and psoriasis. They may also help alleviate symptoms of asthma and other allergic conditions.
  5. Mood Disorders: EPA and DHA have been studied for their potential benefits in managing mood disorders such as depression and anxiety. Omega-3 fatty acids may help regulate neurotransmitter function, reduce inflammation in the brain, and improve symptoms of depression and anxiety.
  6. Pregnancy and Infant Health: Adequate intake of omega-3 fatty acids during pregnancy is important for the development of the baby’s brain and nervous system. DHA is particularly important for fetal brain development, and supplementation may help reduce the risk of preterm birth and improve infant outcomes.
  7. Bone Health: Some research suggests that omega-3 fatty acids may help improve bone density and reduce the risk of osteoporosis, particularly in postmenopausal women.
  8. Skin Health: Omega-3 fatty acids may help maintain skin health by reducing inflammation, protecting against sun damage, and supporting the skin’s barrier function. They may also help improve symptoms of inflammatory skin conditions such as eczema and psoriasis.

Dietary Sources of Omega-3 Fatty Acids:

Fatty fish such as salmon, mackerel, sardines, trout, and herring, Fish oil supplements Flaxseeds and flaxseed oil, Chia seeds, Walnuts, Hemp seeds, Canola oil, Soybean oil

References:

Healthline; https://www.healthline.com: Healthline Media, Inc. is an American website and provider of health information headquartered in San Francisco, California. It was founded in 1999, relaunched in 2006, and established as a standalone entity in January 2016. Healthline has been ranked towards the middle of top-ranking health information websites: It is well organized and easily searchable.

Article on Depression and-Omega-3

Article on Psychosis and Omega-3

Article On Mood Disorder and Omega-3

 

NAC  N-acetyl cysteine

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine, which plays several important roles in the body. NAC has been studied for its potential health benefits, and it is commonly used for various purposes.

NAC  N-acetyl cysteine Uses and benefits

  1. Antioxidant Properties: NAC is a precursor to glutathione, one of the body’s most potent antioxidants. By replenishing glutathione levels, NAC helps protect cells from oxidative damage caused by free radicals, which can contribute to aging, inflammation, and chronic diseases.
  2. Liver Health: NAC has been studied for its potential to support liver health and function. It may help protect the liver from damage caused by toxins, alcohol, and certain medications. NAC is sometimes used as a treatment for acetaminophen (paracetamol) overdose, as it can help prevent liver damage in cases of overdose.
  3. Mucus Clearance: NAC has mucolytic properties, meaning it can help break down and thin mucus in the respiratory tract. This makes it beneficial for conditions associated with excessive mucus production, such as chronic bronchitis, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.
  4. Respiratory Health: Due to its ability to thin mucus and its antioxidant properties, NAC may help improve symptoms and reduce exacerbations in individuals with respiratory conditions such as bronchitis, COPD, asthma, and sinusitis.
  5. Psychiatric Disorders: Some research suggests that NAC may have potential benefits for certain psychiatric disorders, including depression, bipolar disorder, and obsessive-compulsive disorder (OCD). It is thought to exert its effects by modulating glutamate levels in the brain and reducing oxidative stress.
  6. Addiction and Substance Abuse: NAC has been studied for its potential to reduce cravings and withdrawal symptoms in individuals with addiction to substances such as cocaine, nicotine, and cannabis. It may help by restoring glutathione levels, reducing oxidative stress, and modulating neurotransmitter activity.
  7. Neurological Health: NAC has neuroprotective properties and may help protect against neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. It may also support cognitive function and memory.
  8. Polycystic Ovary Syndrome (PCOS): Some research suggests that NAC may help improve insulin sensitivity, reduce inflammation, and regulate menstrual cycles in women with PCOS, a hormonal disorder characterized by irregular periods, ovarian cysts, and insulin resistance.
  9. Exercise Performance: NAC supplementation has been studied for its potential to improve exercise performance and reduce muscle fatigue, possibly by enhancing antioxidant defense mechanisms and reducing oxidative stress during exercise.

It’s important to note that while NAC is generally considered safe for most people when taken at recommended doses, it may interact with certain medications and supplements, and it may not be suitable for everyone, especially those with certain medical conditions or allergies. As with any supplement, it’s advisable to consult with a healthcare professional before starting NAC or any other dietary supplement.

References

Overview of NAC  Michael Berk 2012: Published Paper

Glutathione – The Mother of all Antioxidants: Article Huffington Post

 

Vitamin D-3

Vitamin D is a fat-soluble vitamin that is essential for various physiological functions in the body. Among its different forms, vitamin D3 (cholecalciferol) is the most bioavailable and widely studied. Here are some of the key benefits associated with vitamin D3:

  1. Bone Health: Vitamin D plays a crucial role in maintaining bone health by enhancing the absorption of calcium and phosphorus from the gut. It helps regulate calcium levels in the blood, which is essential for bone mineralization, formation, and remodeling. Adequate vitamin D3 intake can reduce the risk of bone disorders such as osteoporosis and osteomalacia.
  2. Muscle Function: Vitamin D3 is involved in muscle metabolism and function. It helps maintain muscle strength and coordination, which is important for preventing falls and fractures, especially in older adults. Vitamin D deficiency has been linked to muscle weakness and an increased risk of falls.
  3. Immune System Support: Vitamin D3 plays a role in modulating the immune system and has been shown to enhance the function of immune cells, including T cells and macrophages. Adequate vitamin D levels may help reduce the risk of infections, autoimmune diseases, and inflammatory conditions.
  4. Cardiovascular Health: Some research suggests that vitamin D3 may have protective effects on the cardiovascular system. It may help lower blood pressure, improve endothelial function, reduce inflammation, and decrease the risk of heart disease and stroke. However, more studies are needed to fully understand the relationship between vitamin D and cardiovascular health.
  5. Cancer Prevention: There is evidence to suggest that vitamin D3 may have anticancer properties and may help reduce the risk of certain types of cancer, including colorectal, breast, prostate, and pancreatic cancer. Vitamin D may inhibit cell proliferation, promote apoptosis (cell death), and reduce angiogenesis (formation of new blood vessels) in cancer cells.
  6. Mood and Mental Health: Vitamin D3 receptors are found in various areas of the brain, and vitamin D deficiency has been associated with an increased risk of depression, seasonal affective disorder (SAD), and other mood disorders. Some studies suggest that vitamin D supplementation may help improve mood and alleviate symptoms of depression and anxiety.
  7. Weight Management: There is evidence to suggest that vitamin D3 may play a role in regulating body weight and metabolism. Adequate vitamin D levels have been associated with a lower risk of obesity and metabolic syndrome. Vitamin D supplementation may also help support weight loss efforts when combined with a healthy diet and exercise.
  8. Brain Health and Cognitive Function: Vitamin D receptors are present in the brain, and vitamin D3 has been implicated in various aspects of brain health and cognitive function. Adequate vitamin D levels may help reduce the risk of cognitive decline, dementia, and Alzheimer’s disease, although more research is needed in this area.

It’s important to note that while vitamin D3 offers many potential health benefits, excessive intake of vitamin D supplements can lead to toxicity, causing symptoms such as nausea, vomiting, weakness, and kidney damage. Therefore, it’s important to follow recommended dosage guidelines and consult with a healthcare professional before starting any new supplement regimen, especially if you have underlying health conditions or are taking medications. Additionally, vitamin D3 is primarily obtained through exposure to sunlight, and consuming a balanced diet that includes vitamin D-rich foods such as fatty fish, fortified dairy products, and egg yolks can help maintain optimal vitamin D levels.

References:

Vitamin D-3 Graphic

Vitamin D3 The Underrated Essential

Vitamin-D3 Supplement Dose

 

Ginko Biloba

Ginkgo biloba is a popular herbal supplement derived from the leaves of the Ginkgo biloba tree. It has been used for centuries in traditional medicine, particularly in Chinese medicine, and is believed to offer several potential health benefits. While scientific research on its efficacy is mixed, some studies suggest that Ginkgo biloba may provide the following benefits:

  1. Improvement in Cognitive Function: Ginkgo biloba is often touted for its potential to enhance memory, concentration, and overall cognitive function, particularly in older adults. Some research suggests that it may help improve blood flow to the brain, protect against oxidative stress, and enhance neurotransmitter function, which could contribute to cognitive enhancement.
  2. Support for Mental Health: There is some evidence to suggest that Ginkgo biloba may have antidepressant and anxiolytic effects. It may help modulate neurotransmitter activity in the brain, such as serotonin and dopamine, which are involved in mood regulation.
  3. Antioxidant Properties: Ginkgo biloba contains flavonoids and terpenoids, which have antioxidant properties. These compounds help neutralize harmful free radicals in the body, reducing oxidative damage to cells and tissues and potentially lowering the risk of chronic diseases such as heart disease and cancer.
  4. Improved Circulation: Ginkgo biloba has vasodilatory effects, meaning it helps widen blood vessels and improve blood flow throughout the body. This may be beneficial for conditions associated with poor circulation, such as peripheral artery disease (PAD), Raynaud’s disease, and erectile dysfunction.
  5. Reduced Inflammation: Some studies suggest that Ginkgo biloba has anti-inflammatory effects, which may help alleviate symptoms of inflammatory conditions such as arthritis and asthma. By reducing inflammation, it may also have potential benefits for cardiovascular health and overall immune function.
  6. Eye Health: Ginkgo biloba extract is sometimes used to support eye health and vision, particularly in individuals with conditions such as glaucoma and age-related macular degeneration (AMD). Its antioxidant properties may help protect against oxidative damage to the eyes and improve blood flow to the retina.
  7. Symptom Relief in Alzheimer’s Disease and Dementia: While research results are mixed, some studies suggest that Ginkgo biloba may help alleviate symptoms of Alzheimer’s disease and other forms of dementia, such as memory loss and cognitive decline. However, more research is needed to confirm its effectiveness in this regard.

References:

12 Benefits of Ginkgo Biloba:  Healthline Article

 

Zinc Supplements

Zinc is an essential trace mineral that plays a vital role in numerous biological processes. Supplementing with zinc can provide various health benefits, particularly for individuals with a zinc deficiency or those needing extra zinc for specific health conditions. Here are some key benefits of zinc supplements:

  1. Immune Support: Zinc is crucial for maintaining a healthy immune system. It helps in the development and function of immune cells, reduces the duration and severity of colds and other infections, and has antiviral properties.
  2. Wound Healing: Zinc is essential for proper wound healing. It supports cell growth and division, collagen synthesis, and inflammatory response, all of which are important for tissue repair.
  3. Skin Health: Zinc plays a significant role in maintaining healthy skin. It helps manage acne by regulating oil production, reducing inflammation, and supporting the healing of damaged skin. Zinc may also improve conditions like eczema and psoriasis.
  4. Reproductive Health: Zinc is important for reproductive health in both men and women. In men, it contributes to healthy sperm production and testosterone levels. In women, zinc supports ovarian function and hormone balance.
  5. Cognitive Function: Adequate zinc levels are essential for brain health and cognitive function. Zinc deficiency has been linked to impaired cognitive development in children and may contribute to age-related cognitive decline.
  6. Antioxidant Properties: Zinc has antioxidant properties that help protect cells from oxidative stress and damage caused by free radicals. This can reduce the risk of chronic diseases such as heart disease and cancer.
  7. Eye Health: Zinc is important for maintaining healthy vision. It helps transport vitamin A from the liver to the retina, where it is converted into melanin, a protective pigment. Zinc may also reduce the risk of age-related macular degeneration (AMD).
  8. Growth and Development: Zinc is crucial for proper growth and development, especially in children and adolescents. It supports cell growth, DNA synthesis, and protein production.
  9. Metabolism and Energy Production: Zinc is involved in numerous enzymatic reactions that are essential for metabolism and energy production. It helps in the breakdown of carbohydrates, proteins, and fats, providing energy for the body.
  10. Mood and Mental Health: Some studies suggest that zinc may play a role in mood regulation and mental health. Zinc deficiency has been associated with an increased risk of depression and anxiety. Supplementing with zinc may help improve symptoms in individuals with these conditions.
  11. Hormone Regulation: Zinc is involved in the synthesis and regulation of various hormones, including insulin, thyroid hormones, and sex hormones. Adequate zinc levels are important for maintaining hormonal balance and metabolic health.

It’s important to use zinc supplements as directed and not exceed the recommended dosage, as excessive zinc intake can lead to adverse effects such as nausea, vomiting, diarrhea, and interference with the absorption of other essential minerals like copper. Always consult with a healthcare professional before starting any new supplement regimen to ensure it is appropriate for your specific health needs.

 

References:

Zinc Supplements Benefits, Dosage, and Side Effects: Healthline Article